Nog een artikel over magnesium bij hartfalen: nu over het effect van magnesium- suppletie op het CRP (de bekende marker voor ontstekingen in het lichaam): Magnesium verlaagde het CRP bij mensen met hartfalen (die, in vergelijking met mensen zonder hartfalen, een hogere CRP waarde en een lager serum-magnesium hebben).
http://www.ncbi.nlm.nih.gov/pubmed/17479208
Eur J Nutr. 2007 Jun;46(4):230-7. .
Magnesium and C-reactive protein in heart failure: an anti-inflammatory effect of magnesium administration?
Almoznino-Sarafian D, Berman S, Mor A, Shteinshnaider M, Gorelik O, Tzur I, Alon I, Modai D, Cohen N.
Dept. of Internal medicine F, Assaf Harofeh Medical Center, Zerifin 70300, Israel.
Abstract
BACKGROUND: Little is known about the relationship between serum magnesium (Mg) and C-reactive protein (CRP) in heart failure (HF).
AIM OF THE STUDY: To investigate the relationship, if any, between serum Mg and CRP in HF patients and, concomitantly, to test a hypothesis that Mg supplementation might affect serum CRP levels.
METHODS: Serum Mg and CRP were evaluated in 68 patients with chronic systolic HF leading to hospital admission and 65 patients requiring hospitalization for other causes. Following 5 weeks, serum Mg, CRP and intracellular Mg were reevaluated in 17 HF patients after administration of oral Mg citrate 300 mg/day (group A), and 18 untreated HF patients (group B ).
In order to obtain Gaussian distribution, logarithmic transformation of CRP was performed.
RESULTS: Inverse correlation was found between serum Mg and log CRP (r = -0.28, P = 0.002).
Compared to controls, patients with HF demonstrated higher baseline CRP levels, independent of coexisting conditions, and lower serum Mg values.
Following Mg treatment, log CRP decreased from 1.4 +/- 0.4 to 0.8 +/- 0.3 in group A (P < 0.001).
No significant changes in log CRP were demonstrable in group B.
Serum Mg (mmol/l) rose significantly in group A (0.74 +/- 0.04-0.88 +/- 0.08, P < 0.001), and to a lesser extent in group B (0.82 +/- 0.08-0.88 +/- 0.08, P = 0.04).
Intracellular Mg significantly increased only in Mg-treated group A (P = 0.01).
CONCLUSIONS: Oral Mg supplementation to HF patients significantly attenuates blood levels of CRP, a biomarker of inflammation. Targeting the inflammatory cascade by Mg administration might prove a useful tool for improving the prognosis in HF.
PMID: 17479208 [PubMed - indexed for MEDLINE]
